Patient-Centered Network of Learning Health Systems: Developing a resource for clinical translational research





2019/9/6 0:00:00

The Patient-Centered Network of Learning Health Systems (LHSNet) Clinical Data Research Network (CDRN) is 1 of 13 CDRNs assembled to create, in partnership with 20 Patient-Powered Research Networks (PPRN) [1], a National Patient-Centered Clinical Research Network (PCORnet) to support pragmatic trials and comparative effectiveness research. The PCORnet was assembled under the auspices of the Patient-Centered Outcomes Research Institute (PCORI) as a distributed research network to support observational and interventional comparative effectiveness research across participating CDRNs, PPRNs, and external contributors [2, 3–5].

The LHSNet comprises 9 participating organizations and includes data on nearly 10 million patients. The LHSNet ( Web site provides a map illustrating the geographic locations of the participating sites and describes each of the partnering organizations in the network [6]. 

The LHSNet includes 6 health systems (Mayo Clinic, Allina Health System, Essentia Health, Intermountain Health Care, University of Michigan, and Ohio State University); 1 health plan (Medica Research Institute); 1 data partner based in a university (Arizona State University); and 1 local public health department (Olmsted County Public Health Services). A key distinctive feature of LHSNet is its commitment to integrate, in 1 network, health systems, public health offices, and payers to operationalize the vision of a learning health system (LHS) [7]. As defined by the National Academy of Medicine, an LHS is one “in which progress in science, informatics, and care culture align to generate new knowledge as an ongoing, natural by-product of the care experience, and seamlessly refine and deliver best practices for continuous improvement in health and healthcare [8].” 

The partners in LHSNet represent a diversity of health-care stakeholders, and their collaboration within 1 network uniquely positions the LHSNet to experience and address the challenges of deploying the LHS vision [7].

学习健康的以病人为中心的网络系统(LHSNet)临床资料研究网络(CDRN)是1 13 CDRNs创建、组装与20 Patient-Powered合作研究网络(PPRN)[1],一个全国性的以病人为中心的临床研究网络(PCORnet)支持务实的试验和比较效益研究。PCORnet是在以患者为中心的结果研究所(PCORI)的支持下组建的,作为一个分布式研究网络,支持参与CDRNs、PPRNs和外部贡献者之间的观察性和介入性比较有效性研究[2,3 - 5]。

LHSNet由9个参与组织组成,包括近1000万患者的数据。LHSNet (网站提供了一幅地图,说明了参与网站的地理位置,并描述了网络[6]中的每个合作组织。

LHSNet包括6个卫生系统(Mayo Clinic、Allina health System、essity health、Intermountain health Care、University of Michigan和Ohio State University);1卫生计划(医学研究所);1所大学(亚利桑那州立大学)的数据合作伙伴;1个地方公共卫生部门(奥姆斯特德县公共卫生服务)。LHSNet的一个重要特点是,它致力于将卫生系统、公共卫生办事处和支付方整合到一个网络中,以实现学习型卫生系统(LHS)[7]的愿景。根据美国国家医学院的定义,LHS是“科学、信息学和护理文化的进步结合起来,产生新的知识,作为护理经验的一个持续的、自然的副产品,无缝地细化和提供最佳实践,以持续改进健康和保健[8]。”



Patient-Centered Network of Learning Health Systems: Developing a resource for clinical translational research


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